惰性角膜溃疡

Thisdogwasreferredtoaveterinaryophthalmologistafterthreeweeksofmedicaltherapyforasuperficialulcerwithnoprogressinhealing.Onpresentation,anaxialsuperficialulcer(about30%ofcornealsurfaceinsize)wasobserved.

该犬在接受了三个星期的治疗后，由于浅表角膜溃疡没有愈合而被转诊给兽医眼科医生。临床表现为角膜正中浅表溃疡(约占角膜表面的30%)。

i.Describethepathophysiologyofspontaneouschroniccornealepithelialdefects(SCCEDs)(alsoknownasindolentulcersor‘Boxerulcers’).

请描述自发性慢性角膜上皮缺损(SCCEDs)的病理生理学(也被称为惰性溃疡或“拳师溃疡”)。

ii.HowwouldyoudiagnoseaSCCED?

如何诊断SCCED？

i.SCCEDsarechronicsuperficialepithelialulcersthatfailtoresolvethroughnormalwoundhealingprocesses.Theyhavebeendocumentedinalmosteverycaninebreed.Itislikelythattheinitiatingeventindogsisminorsuperficialtrauma.Histologyshowstheepitheliumtobepoorlyattachedtotheunderlyingcornealstromaandthereisevidenceofdysmaturationorlossofthenormalepithelialarchitecture.Avariableamountofstromalfibroplasia,vascularization,andleukocyticinfiltrateoccurs.Thereiseithernoepithelialbasementmembraneoronlysmalldiscontinuoussegmentsofbasementmembraneonthesurfaceoftheexposedstroma.Ahyalinizedacellularzone